Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane
نویسندگان
چکیده
منابع مشابه
Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane.
BACKGROUND Liver/kidney microsomal antibody type 1 (LKM1) is the marker of type 2 autoimmune hepatitis (AIH) and is detected in up to 6% of patients with hepatitis C virus (HCV) infection. It recognises linear and conformational epitopes of cytochrome P450IID6 (CYP2D6) and may have liver damaging activity, provided that CYP2D6 is accessible to effector mechanisms of autoimmune attack. METHODS...
متن کاملLiver/kidney microsomal antibody type 1 and liver cytosol antibody type 1 concentrations in type 2 autoimmune hepatitis.
BACKGROUND Liver/kidney microsomal antibody type 1 (LKM1) and liver cytosol antibody type 1 (LC1) are the serological markers of type 2 autoimmune hepatitis (AIH). AIMS Since LKM1 and LC1 react against two distinct liver specific autoantigens (cytochrome P450IID6 (CYP2D6) and a 58 kDa cytosolic polypeptide respectively), the aim was to see whether LKM1 and LC1 concentrations correlate with li...
متن کاملSugar transport across the hepatocyte plasma membrane.
Physiologically D-glucose transport across the hepatocyte plasma membrane differs from that in most other cells. Most cells in the body extract glucose from the blood as a source of energy or carbon. The liver on the other hand responds to its environment and acts as a 'glucostat'. As the level of glucose in the blood rises, i.e. during feeding, the liver must take it up and store it as glycoge...
متن کاملTopology inversion of CYP2D6 in the endoplasmic reticulum is not required for plasma membrane transport.
The presence of CYP2D6 at the surface of isolated rat and human hepatocytes and its recognition by autoantibodies were reported recently. We wondered whether the unexpected outside orientation at the plasma membrane could be related to topological inversion (luminal-oriented form) of cytochrome P450 in the endoplasmic reticulum. To examine the potential role of cDNA polymorphism, a CYP2D6 varia...
متن کاملIdentification of rat hepatocyte plasma membrane proteins using monoclonal antibodies
We have localized and identified five rat hepatocyte plasma membrane proteins using hybridoma technology in combination with morphological and biochemical methods. Three different membrane preparations were used as immunogens: isolated hepatocytes, a preparation of plasma membrane sheets that contained all three recognizable surface domains of the intact hepatocyte (sinusoidal, lateral, and bil...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gut
سال: 2000
ISSN: 0017-5749
DOI: 10.1136/gut.46.4.553